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Computational simulations help to predict the performance of bone tissue scaffolds implanted in vivo

By 14 de January de 2010November 18th, 2020No Comments
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 14.01.2010

Computational simulations help to predict the performance of bone tissue scaffolds implanted in vivo

The supply of oxygen and nutrients from capillaries as well as the mechanical stimuli transmitted to cells are critical factors that influence tissue differentiation. The effect of these two factors can be investigated using mechanobiological computational models. In the study Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach in Biomaterials (doi:10.1016/j.biomaterials.2009.11.063), Clara Sandino and Damien Lacroix from the Institute for Bioengineering of Catalonia (IBEC), and researchers from the Trinity College Dublin (Ireland) have simulated angiogenesis and tissue differentiation in a scaffold to be used for bone tissue engineering.

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