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The fight against the toxic aggregation of proteins according to Darwin

By 14 de June de 2011November 18th, 2020No Comments
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 14.06.2011

The fight against the toxic aggregation of proteins according to Darwin

Researchers headed by Xavier Salvatella, ICREA researcher with the joint program between the Institute for Research in Biomedicine (IRB Barcelona) and the Barcelona Supercomputing Center (BSC), have discovered that certain bonds that keep proteins folded, called disulfide bridges, induce the formation of protein aggregates that are more stable and less toxic for cells than those that don't have them.


According to these scientists, these results would explain the greater presence of these bonds in proteins secreted extracellularly, an environment in which they aggregate more easily. Involving collaboration with researchers at the “Centre de Regulació Genòmica de Barcelona”, the University of Cambridge (UK) and the University of Liège (Belgium), the study has come out in Angewandte Chemie, one of the most prestigious international journal of chemistry.

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