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The toxicity of amyloid fibers depends on their structure

By 20 de September de 2010November 18th, 2020No Comments
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 20.09.2010

The toxicity of amyloid fibers depends on their structure

Major neurodegenerative diseases, such as Parkinson's and Alzheimer's, are related to the development of protein aggregates in the form of amyloid fibers. Despite the relevance of these deposits, little is known about why they are toxic and the mechanisms by which they damage cells. A study recently published in the Journal of Molecular Biology by researchers at the Institute for Research in Biomedicine (IRB Barcelona) and the University of Cambridge, headed by Xavier Salvatella and Christopher Dobson, sheds some light on the origin of the toxic properties of these aggregates.

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