Eventos

Noninvasive pharmaceutical analysis by water nuclear magnetic resonance.

Prof. Bruce Yu, School of Pharmacy University of Maryland.

Abstract: Water is the common solvent used in biomanufacturing and biologics formulation. The concentration of water is much higher than that of the API, excipients and adjuvants. Water nuclear magnetic resonance (wNMR) measurements can be carried out using benchtop instruments, typically within a minute. Most importantly, however, wNMR measurements can be carried out in an in situ and contact-free manner. This opens the door for rapid formulation screening, noninvasive product inspection and contact-free in-line processing monitoring. In this presentation, examples of different wNMR applications will be presented, including flow wNMR as in-line PAT.