Eventos

Speaker: Jeremy Reiter, MD, PhD – Professor & Chair, Department of Biochemistry and Biophysics, School of Medicine – University of California, San Francisco.

Abstract: Hedgehog pathway components and select G protein-coupled receptors (GPCRs) localize to the primary cilium, an organelle specialized for signal transduction. Misactivation of ciliary Hedgehog signaling causes cancers such as basal cell carcinoma and medulloblastoma. Defects in ciliary GPCR function can cause obesity by altering the function of neurons controlling feeding behaviors. I will discuss new data about how human ciliopathies (diseases caused by defective cilia) alter ciliary GPCR signaling to change behavior.